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Warfarin inhibits vitamin K epoxide reductase, blocking synthesis of factors II, VII, IX, X. Monitor with PT/INR.
Reversed with Vitamin K (slow) or FFP/PCC (fast). Teratogenic - avoid in pregnancy.
PharmacologyA 45-year-old presents with crushing chest pain, diaphoresis, and ST elevations in V1-V4. The occluded artery is most likely the LAD.
Anterior STEMI = LAD occlusion. "Widow maker" - high mortality if proximal.
CardiologyLithium causes nephrogenic diabetes insipidus by blocking ADH action on collecting ducts. Treat with amiloride or thiazides.
Also causes hypothyroidism, tremor, and teratogenicity (Ebstein anomaly).
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